Lymphoma (HL & NHL)

Positron emission tomography (PET) is a valuable imaging technique for the evaluation of lymphoma, including both Non-Hodgkin lymphoma (NHL) and Hodgkin's lymphoma. It uses radioactive tracers to detect metabolic and physiological processes in the body. The benefits and applications of PET in lymphoma vary depending on the stage of cancer.

Here is a summary of its applications for each stage:

Stage 1 Lymphoma:

Benefit: PET can help determine the extent of disease involvement and guide treatment decisions.

Application: PET is commonly used to assess the primary tumor and evaluate the presence of lymph node involvement or distant metastases. It aids in staging and treatment planning, including decisions regarding the need for radiation therapy or systemic treatments.

Stage 2 Lymphoma:

Benefit: PET can aid in assessing the extent of lymph node involvement and detecting distant metastases.

Application: PET is employed to evaluate the spread of cancer to nearby lymph nodes and other parts of the body. It assists in staging, determining the appropriate treatment approach, and guiding decisions on the use of radiation therapy, chemotherapy, or targeted therapies.

Stage 3 Lymphoma:

Benefit: PET can help in assessing the extent of lymph node involvement and identifying distant metastases.

Application: PET is used to determine the spread of cancer to lymph nodes, organs, and tissues both near and distant from the primary site. It aids in staging and treatment planning, including determining the need for radiation therapy, chemotherapy, immunotherapy, or stem cell transplantation.

Stage 4 Lymphoma:

Benefit: PET is highly effective in identifying distant metastases and guiding treatment decisions.

Application: PET is crucial in detecting the spread of cancer to distant organs, such as the bone marrow, liver, spleen, or other sites. It helps in determining the most appropriate treatment approach, including systemic therapies, immunotherapy, targeted therapies, or stem cell transplantation.

PET/CT has important applications in both Non-Hodgkin lymphoma and Hodgkin’s lymphoma:

Non-Hodgkin Lymphoma:

Benefit: PET/CT can aid in staging, treatment response assessment, and post-treatment surveillance.

Application: PET/CT is frequently used to stage NHL, determine the extent of disease involvement, and guide treatment decisions. It can assess the response to therapy and aid in determining the need for additional treatment or modification of the treatment plan. PET/CT is also utilized for surveillance after completion of treatment to monitor for recurrence or residual disease.

Hodgkin’s Lymphoma:

Benefit: PET/CT is essential for staging, response assessment, and treatment planning in Hodgkin’s lymphoma.

Application: PET/CT is a standard tool for staging Hodgkin’s lymphoma, aiding in the assessment of disease involvement in lymph nodes and other organs. It plays a crucial role in evaluating treatment response, allowing for early identification of non-responders and guiding treatment modifications. PET/CT also assists in radiation therapy planning and surveillance during follow-up.

In summary, the benefits and applications of PET in lymphoma, including Non-Hodgkin lymphoma and Hodgkin’s lymphoma, encompass staging, identifying lymph node involvement and distant metastases, guiding treatment decisions, monitoring treatment response, and surveillance. PET/CT is particularly valuable in staging, assessing treatment response, and planning treatment strategies for both types of lymphoma.