Multiple Myeloma and Other Plasma Cell Neoplasms

According to the AACR, “Plasma cell neoplasms are diseases in which abnormal plasma cells or myeloma cells form tumors in the bones or soft tissues of the body. Plasma cells develop from B lymphocytes (B cells), a type of white blood cell that is made in the bone marrow. Plasma cell neoplasms can be benign or malignant. The following types of plasma cell neoplasms are cancer:

1. Waldenstrom macroglobulinemia
2. Plasmacytoma
3. Multiple myeloma

The National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) Program estimates some 35,730 people in the United States will be diagnosed with myeloma and that 12,590 will die of the disease in 2023.”

FDG PET/CT Visualizing Multiple Myeloma

National Comprehensive Cancer Network® (NCCN®) Comments on PET/CT and Multiple Myeloma.

Whole-body imaging with low-dose CT or FDG PET/CT is recommended for initial diagnostic workup of patients suspected of having MM or solitary plasmacytoma. Skeletal survey is acceptable in certain circumstances. However, skeletal survey is significantly less sensitive than whole-body low-dose CT and FDG PET/CT in detecting osteolytic lesions in patients with monoclonal plasma cell disorders.

Source: (page 16/109 section Myel-B)

Permission Pending from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Multiple Myeloma Version 3.2023 — December 8, 2022. © National Comprehensive Cancer Network, Inc. 2023. All rights reserved. Accessed August 21, 2023

To view the most recent and complete version of the guideline, go online to Link (page 16/109 section Myel-B)